Novusetin®

Overview

Supporting focus, alertness and cognitive function has a marked impact on quality of life. Just as the body needs proper nutrition for physical health, maintaining cognitive performance also requires targeted support. With advancing age, cells face increased oxidative stress, which makes cognitive nutrition important.

Novusetin is formulated to strengthen cognitive health by managing oxidative stress and supporting a balanced inflammatory response.

It is a premium fisetin extract derived from the Japanese wax tree (Rhus succedanea). It is standardized to contain at least 95% fisetin and offers high stability and solubility.

Research conducted at the Salk Institute for Biological Studies shows that fisetin protects neurological function, supports cellular integrity, maintains healthy brain function and supports the growth of neuronal cells.

Applications

Novusetin can be used as a sole ingredient or in combination with other ingredients in food supplements, foods and beverages.

Key features

It is standardized to contain at least 95% fisetin.

Fisetin is a naturally occurring flavonol (a bioflavonoid antioxidant) derived from the Japanese wax tree Rhus succedanea.

It is reported to increase intracellular glutathione levels and activate key neurotrophic factor signaling pathways.

It has been reported to reduce lipoxygenase activity and to exert anti-inflammatory activity against microglial cells.

It is pure and non-GMO, and free of preservatives, additives, and artificial colors and flavors.

In 2022, Health Canada assigned Novusetin® (fisetin extract) a Natural Product Number (NPN: 80117026).

It is reported to protect against oxidative stress, reducing cellular damage.

Mechanism of action

Novusetin stands out for its ability to cross the blood-brain barrier and supports signaling pathways associated with long-term memory.

As a flavonol in the bioflavonoid polyphenol family, it acts as a potent antioxidant.

Fisetin is reported to increase intracellular glutathione levels and activate key neurotrophic factor signaling pathways.

Selected related publications: Maher P., Neurochemistry International, September 2024;178:105805. — Tang X. et al., Biomedicines, November 2023;11(11):2878. — Shams S. et al., Frontiers in Pharmacology, 2022;13:1015835.