NEM® Intense

Overview

NEM® is the original eggshell membrane ingredient developed for optimal joint function and has been the leader in this field for over 15 years.

With a total of 16 published clinical studies and more than 600 participants, it has more joint health studies in healthy populations than any other eggshell membrane ingredient.

In human clinical studies, NEM® has been shown to support healthy joints, reducing pain, stiffness and cartilage breakdown in as little as 4–11 days.

It is sustainably sourced from US-domestic eggshells and offered in a convenient daily dose of 500 mg. According to clinical studies, a single daily 500 mg dose of NEM® has shown significant improvements in stiffness, range of motion (ROM) and pain reduction within just 7 days.

Applications

NEM®’s effective 500 mg dose offers extensive formulation flexibility and provides a comprehensive, once-daily joint health solution.

In addition to being a potent standalone ingredient, it also performs well in combination formulas.

The Phytonet Pharmaceutical Division offers manufacturing support in a range of dosage forms.

Key features

NEM® has a verified mechanism of action: it exerts direct immunomodulatory effects by reducing pro-inflammatory cytokines (TNF-α, IL-1β, CRP) in human immune cells, and it indirectly modulates NF-κB activation through an oral tolerance mechanism in the gut-associated lymphoid tissue (GALT).

Significant benefits have been documented using standardized joint health assessment methods — WOMAC, VAS and the Lequesne Functional Index (LFI).

It has a positive effect on pain biomarkers, particularly PGRI/PGE2 and LOX/COX.

It is rigorously tested for purity and potency; it has been well tolerated in clinical studies and is supported by extensive safety data.

It is reported that it may help reduce exercise-induced joint pain.

It is reported that it may help reduce joint aches and pains.

Mechanism-of-action studies suggest that it may help reduce cartilage degradation associated with normal wear and tear.

Mechanism of action

NEM® has a verified mechanism of action.

Direct effect: It exerts an immunomodulatory effect by reducing pro-inflammatory cytokines (TNF-α, IL-1β, CRP) in human immune cells.

Indirect effect: It modulates NF-κB activation through an oral tolerance mechanism in the gut-associated lymphoid tissue (GALT).

It has also been reported to have a positive effect on the pain biomarkers PGRI/PGE2 and LOX/COX.