HiRaDophilus®

Overview

HiRaDophilus® is a patented probiotic concept composed of three well-characterized autochthonous strains originating from the Balkan region: Lactobacillus fermentum, Lactobacillus helveticus and Streptococcus thermophilus.

These strains are part of the natural microbial ecosystem of Southeast Europe and have adapted over centuries to regional dietary habits and environmental conditions.

Historically a crossroads of European cultures, the Balkan region has developed a distinct and diverse microbial footprint, which is also reflected in the functional properties of these strains.

Key features

Autochthonous strains are highly relevant for targeted probiotic applications due to their strong adhesion capacity, robust colonization potential and ability to support intestinal barrier integrity.

In vitro and in vivo studies indicate proteolytic, antimicrobial and immunomodulatory activity. This includes inhibition of Clostridium difficile and Clostridium perfringens, as well as measurable effects on gut barrier function and microbial balance.

HiRaDophilus® was developed in collaboration with the Institute of Molecular Genetics and Genetic Engineering (IMGGI), a leading regional research institution with long-standing expertise in the collection, preservation and functional characterization of human-origin strains.

Each strain in the concept is identity-verified and evaluated for safety, stability and viability. This ensures its suitability for use in food supplements, functional foods and fermented dairy applications.

Strong adhesion and colonization potential.

Documented proteolytic and antimicrobial activity.

Immunomodulatory potential demonstrated in preclinical models.

Native adaptation to Southeast European dietary and microbial environments.

Mechanism of action

Thanks to their strong capacity to adhere to the intestinal epithelium and their robust colonization potential, autochthonous strains support intestinal barrier integrity.

In vitro and in vivo studies indicate proteolytic, antimicrobial and immunomodulatory activity, including inhibition of Clostridium difficile and Clostridium perfringens.

Immunomodulatory potential has been demonstrated in preclinical models. The strains’ native adaptation to Southeast European dietary and microbial environments provides a functional advantage in regional applications.